Decoding and Rewiring Redox Signal Transduction Pathways.Redox signal transduction is part of the normal physiology of all organisms including plants, humans, and bacteria. Cells possess intricate enzymatic circuitry to sense redox stimuli in their microenvironment, communicate these changes downstream, and make phenotypic modulations in response to redox changes. Our lab views cellular redox signal transduction pathway as a logic circuit that responds to specific redox inputs via metalloprotein sensors and transmits the signal down to genetic response regulators to induce phenotypic outputs. Dysregulation of redox sensing/signaling mechanisms and consequent cellular redox imbalance have been implicated in a variety of diseases including neurological disorders and cancer. The long-term goal of this research program is to develop molecular strategies that rewire signal transduction circuitry of biological redox reagents involved in health and disease. This research program is sponsored by National Institute of Health (General Medicine)
|
Relevant Publications
An enzymatic method for precise oxygen affinity measurements over nanomolar-to-millimolar concentration regime.
Ria Sanyal, Ambika Bhagi-Damodaran* J. Biological Inorganic Chem ASAP (2020) https://doi.org/10.1007/s00775-019-01750-6 |