Gas tunnel engineering of prolyl hydroxylase domain reprograms hypoxia signaling in cells
Windsor P, Ouyang H, da Costa JAG, Damodaran AR, Chen Y, Bhagi-Damodaran A. bioRxiv. (2023) https://doi.org/10.1101/2023.08.07.552357 |
Understanding ATP binding to DosS catalytic domain with a short ATP-lid
Larson GW, Windsor PK, Smithwick E, Shi K, Aihara H, Damodaran, AR, Bhagi-damodaran A, Biochem. 2023. https://doi.org/10.1021/acs.biochem.3c00306 |
Electrostatically regulated active site assembly governs reactivity in non-heme iron halogenases
Smithwick ER, Wilson RH, Chatterjee S, Pu Y, Dalluge JJ, Damodaran AR, Bhagi-Damodaran A. ACS Catal. (2023) https://doi.org/10.1021/acscatal.3c02531 |
Metalloprotein enabled redox signal transduction in microbes
Williams MT, Yee E, Larson GW, Apiche EA, Damodaran AR, Bhagi-Damodaran A. Curr. Opin. Chem. Biol. (2023) https://doi.org/10.1016/j.cbpa.2023.102331 |
Integrating UV-Vis Spectroscopy and Oxygen Optode for Accurate Determination of Oxygen Affinity of Proteins
Damodaran AR, Bhagi-Damodaran A. Oxygen Sensing, Methods in Molecular Biology. (2023) https://doi.org/10.1007/978-1-0716-3080-8_1 |
An enzymatic method for precise oxygen affinity measurements over nanomolar-to-millimolar concentration regime.
Ria Sanyal, Ambika Bhagi-Damodaran* J. Biological Inorganic Chem ASAP (2020) https://doi.org/10.1007/s00775-019-01750-6 |
Understanding and Modulating Metalloenzymes with Unnatural Amino Acids, Non-Native Metal Ions, and Non-Native Metallocofactors.
Evan Mirts, Ambika Bhagi-Damodaran, Yi Lu. Accounts of Chemical Research. 52, 4, 935-944 (2019) https://doi.org/10.1021/acs.accounts.9b00011 |
Oxygen Reduction by Biosynthetic Models of Cytochrome c Oxidase: Insights into Role of Proton Transfer Residues from Perturbed Active Sites Models of CcO.
Sohini Mukherjee, Manjistha Mukherjee, Arnab Mukherjee, Ambika Bhagi-Damodaran, Yi Lu, Abhishek Dey. ACS Catal. 8(9), 8915 (2018) https://doi.org/10.1021/acscatal.8b02240 |
Heme redox potentials hold the key to reactivity differences between nitric oxide reductase and heme-copper oxidase.
Ambika Bhagi-Damodaran, Julian H Reed, Qianhong Zhu, Yelu Shi, Parisa Hosseinzadeh, Braddock A Sandoval, Kevin A Harnden, Shuyan Wang, Madeline R Sponholtz, Evan N Mirts, Sudharsan Dwaraknath, Yong Zhang, Pierre Moënne-Loccoz, Yi Lu. Proc. Nat. Acad. Sci. U.S.A. 201720298 (2018) https://doi.org/10.1073/pnas.1720298115 |
Manganese and Cobalt in the Nonheme-Metal-Binding Site of a Biosynthetic Model of Heme-Copper Oxidase Superfamily Confer Oxidase Activity through Redox-Inactive Mechanism.
Julian H Reed, Yelu Shi, Qianhong Zhu, Saumen Chakraborty, Evan N Mirts, Igor D Petrik, Ambika Bhagi-Damodaran, Matthew Ross, Pierre Moënne-Loccoz, Yong Zhang, Yi Lu. J. Am. Chem. Soc. 139(35) 12209 (2017) https://doi.org/10.1021/jacs.7b05800 |
Insights Into How Heme Reduction Potentials Modulate Enzymatic Activities of a Myoglobin-based Functional Oxidase.
Ambika Bhagi-Damodaran, Maximilian Kahle, Yelu Shi, Yong Zhang, Pia Adelroth, Yi Lu. Angew Chem. Int. Ed. 56, 6622 (2017) https://doi.org/10.1002/anie.201701916 |
Why copper is preferred over iron for oxygen activation and reduction in haem-copper oxidases.
Ambika Bhagi-Damodaran, Matthew A. Michael, Qianhong Zhu, Julian Reed, Braddock A. Sandoval, Evan N. Mirts, Saumen Chakraborty, Pierre Moënne-Loccoz, Yong Zhang, Yi Lu. Nature Chemistry, 9, 257–263 (2017) https://doi.org/10.1038/nchem.2643 |
Using biosynthetic models of heme-copper oxidase and nitric oxide reductase in myoglobin to elucidate structural features responsible for enzymatic activities.
Ambika Bhagi-Damodaran, Igor Petrik, Yi Lu. Isr. J. Chem. 56(9), 1869 (2016) https://doi.org/10.1002/ijch.201600033 |
Design and engineering of artificial oxygen-activating metalloenzymes.
Flavia Nastri, Marco Chino, Ornella Maglio, Ambika Bhagi-Damodaran, Yi Lu, Angela Lombardi. Chemical Society Reviews 45 (18), 5020 (2017) https://doi.org/10.1039/C5CS00923E |
Compound Q is finally deciphered.
Ambika Bhagi-Damodaran, Yi Lu. Inorg. Chem. Front. 2, 824 (2015) https://doi.org/10.1039/C5QI00117J |
Systematic tuning of heme redox potentials and its effects on oxygen reduction rates in a designed oxidase in myoglobin.
Ambika Bhagi-Damodaran, Igor D. Petrik, Nicholas M. Marshall, Howard Robinson, Yi Lu. J. Am. Chem. Soc. 136, 11882 (2014) https://doi.org/10.1021/ja5054863 |
Metalloproteins containing cytochrome, iron-sulfur or copper redox centers.
Jing Liu, Saumen Chakraborty, Parisa Hosseinzadeh, Yang Yu, Shiliang Tian, Igor Petrik, Ambika Bhagi, Yi Lu. Chem. Rev. 114(8), 4366 (2014) https://doi.org/10.1021/cr400479b |
Fluorescein Prototropism within Poly(ethylene glycol)s and Their Aqueous Mixtures.
Ambika Bhagi, Shubha Pandey, Ashish Pandey, Siddharth Pandey. J. Phys. Chem. B. 117, 5230 (2013) https://doi.org/10.1021/jp402113s |